Neurite outgrowth on nanofiber scaffolds with different orders, structures, and surface properties.

ABSTRACT: Electrospun nanofibers can be readily assembled into various types of scaffolds for applications in neural tissue engineering. The objective of this study is to examine and understand the unique patterns of neurite outgrowth from primary dorsal root ganglia (DRG) cultured on scaffolds of electrospun nanofibers having different orders, structures, and surface properties. We found that the neurites extended radially outward from the DRG main body without specific directionality when cultured on a nonwoven mat of randomly oriented nanofibers. In contrast, the neurites preferentially extended along the long axis of fiber when cultured on a parallel array of aligned nanofibers. When seeded at the border between regions of aligned and random nanofibers, the same DRG simultaneously expressed alig

SUBMITTER: Xie J 

PROVIDER: S-EPMC2765554 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature