A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.

ABSTRACT: Pregnant women are advised to abstain from alcohol despite insufficient evidence on the fetal consequences of moderate prenatal alcohol use. Mendelian randomization could help distinguish causal effects from artifacts due to residual confounding and measurement errors; however, polymorphisms reliably associated with alcohol phenotypes are needed. We aimed to test whether alcohol dehydrogenase (ADH) gene variants were associated with alcohol use before and during pregnancy. Ten variants in four ADH genes were genotyped in women from South-West England. Phenotypes of interest were quantity and patterns of alcohol consumption before and during pregnancy, including quitting alcohol following pregnancy recognition. We tested single-locus associations between genotypes and phenotypes with regres

SUBMITTER: Zuccolo L 

PROVIDER: S-EPMC2766294 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature