Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility.

ABSTRACT: Ten to 15% of couples are infertile, with the most common causes being linked to the production of few or no oocytes or sperm. Yet, our understanding of human germ cell development is poor, at least in part due to the inaccessibility of early stages to genetic and developmental studies. Embryonic stem cells (ESCs) provide an in vitro system to study oocyte development and potentially treat female infertility. However, most studies of ESC differentiation to oocytes have not documented fundamental properties of endogenous development, making it difficult to determine the physiologic relevance of differentiated germ cells. Here, we sought to establish fundamental parameters of oocyte development during ESC differentiation to explore suitability for basic developmental genetic applications usi

SUBMITTER: Nicholas CR 

PROVIDER: S-EPMC2766296 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature