Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits.

ABSTRACT: Genome-wide gene expression studies may provide substantial insight into gene activities and biological pathways differing between tissues and individuals. We investigated such gene expression variation by analyzing expression profiles in brain tissues derived from eight different brain regions and from blood in 12 monkeys from a biomedically important non-human primate model, the vervet (Chlorocebus aethiops sabaeus). We characterized brain regional differences in gene expression, focusing on transcripts for which inter-individual variation of expression in brain correlates well with variation in blood from the same individuals. Using stringent criteria, we identified 29 transcripts whose expression is measurable, stable, replicable, variable between individuals, relevant to brain functio

SUBMITTER: Jasinska AJ 

PROVIDER: S-EPMC2766297 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature