Regulatory divergence in Drosophila melanogaster and D. simulans, a genomewide analysis of allele-specific expression.

ABSTRACT: Species-specific regulation of gene expression contributes to the development and maintenance of reproductive isolation and to species differences in ecologically important traits. A better understanding of the evolutionary forces that shape regulatory variation and divergence can be developed by comparing expression differences among species and interspecific hybrids. Once expression differences are identified, the underlying genetics of regulatory variation or divergence can be explored. With the goal of associating cis and/or trans components of regulatory divergence with differences in gene expression, overall and allele-specific expression levels were assayed genomewide in female adult heads of Drosophila melanogaster, D. simulans, and their F1 hybrids. A greater proportion of cis dif

SUBMITTER: Graze RM 

PROVIDER: S-EPMC2766316 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature