VANLO--interactive visual exploration of aligned biological networks.

ABSTRACT:

Background

Protein-protein interaction (PPI) is fundamental to many biological processes. In the course of evolution, biological networks such as protein-protein interaction networks have developed. Biological networks of different species can be aligned by finding instances (e.g. proteins) with the same common ancestor in the evolutionary process, so-called orthologs. For a better understanding of the evolution of biological networks, such aligned networks have to be explored. Visualization can play a key role in making the various relationships transparent.

Results

We present a novel visualization system for aligned biological networks in 3D space that naturally embeds existing 2D layouts. In addition to displaying the intra-network connectivities, we also provide insight

SUBMITTER: Brasch S 

PROVIDER: S-EPMC2766391 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature