A role for immune responses against non-CS components in the cross-species protection induced by immunization with irradiated malaria sporozoites.

ABSTRACT: Immunization with irradiated Plasmodium sporozoites induces sterile immunity in rodents, monkeys and humans. The major surface component of the sporozoite the circumsporozoite protein (CS) long considered as the antigen predominantly responsible for this immunity, thus remains the leading candidate antigen for vaccines targeting the parasite's pre-erythrocytic (PE) stages. However, this role for CS was questioned when we recently showed that immunization with irradiated sporozoites (IrrSpz) of a P. berghei line whose endogenous CS was replaced by that of P. falciparum still conferred sterile protection against challenge with wild type P. berghei sporozoites. In order to investigate the involvement of CS in the cross-species protection recently observed between the two rodent parasites P. b

SUBMITTER: Mauduit M 

PROVIDER: S-EPMC2766644 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature