Molecular NMR T2 values can predict cartilage stress-relaxation parameters.

ABSTRACT: Articular cartilage lines synovial joints and functions as a low-friction deformable tissue to enable smooth and stable joint articulation. The objective of this study was to determine the relationships between cartilage stress-relaxation properties and the collagen and GAG NMR transverse relaxation times (T(2)) toward understanding mechanisms of cartilage viscoelasticity. Stress-relaxation tests were performed on both cultured and enzymatically digested bovine cartilage, followed by measurements of both the collagen and GAG T(2) using the Call-Purcell-Meiboom-Gill pulse sequence. The peak and equilibrium stresses were correlated with the GAG T(2), and the stress-relaxation time constant was correlated with the collagen T(2). Multiple linear regression models were successful in using the s

SUBMITTER: June RK 

PROVIDER: S-EPMC2766774 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature