Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung.

ABSTRACT:

Background

Allergic asthma results from inappropriate T(H)2-mediated inflammation. Both IL-4 and IL-13 contribute to asthma pathogenesis, but IL-4 predominantly drives T(H)2 induction, whereas IL-13 is necessary and sufficient for allergen-induced airway hyperresponsiveness and goblet cell hyperplasia. Although these 2 cytokines share signaling components, the molecular mechanisms by which they mediate different phases of the allergic asthmatic response remain elusive.

Objective

We sought to clarify the role or roles of IL-4 and IL-13 in asthma-pathogenesis.

Methods

We used DNA Affymetrix microarrays to profile pulmonary gene expression in BALB/c mice inoculated intratracheally with ragweed pollen, house dust mite, IL-4, IL-13, or both cytokines. IL-13 dependence was

SUBMITTER: Lewis CC 

PROVIDER: S-EPMC2766779 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature