Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease.

ABSTRACT:

Background

Recently, a large meta-analysis including over 28,000 participants identified nine different loci with association to serum uric acid (UA) levels. Since elevated serum UA levels potentially cause gout and are a possible risk factor for coronary artery disease (CAD) and myocardial infarction (MI), we performed two large case-control association analyses with participants from the German MI Family Study. In the first study, we assessed the association of the qualitative trait gout and ten single nucleotide polymorphisms (SNP) markers that showed association to UA serum levels. In the second study, the same genetic polymorphisms were analyzed for association with CAD.

Methods and findings

A total of 683 patients suffering from gout and 1,563 healthy controls from the

SUBMITTER: Stark K 

PROVIDER: S-EPMC2766838 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature