Ontology highlight
ABSTRACT:
SUBMITTER: Lin YG
PROVIDER: S-EPMC2766914 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Clinical cancer research : an official journal of the American Association for Cancer Research 20080901 17
<h4>Purpose</h4>The Aurora kinase family plays pivotal roles in mitotic integrity and cell cycle. We sought to determine the effects of inhibiting Aurora kinase on ovarian cancer growth in an orthotopic mouse model using a small molecule pan-Aurora kinase inhibitor, MK-0457.<h4>Experimental design</h4>We examined cell cycle regulatory effects and ascertained the therapeutic efficacy of Aurora kinase inhibition both alone and combined with docetaxel using both in vitro and in vivo ovarian cancer ...[more]