Locus for familial migrainous vertigo disease maps to chromosome 5q35.

ABSTRACT:

Objectives

Migrainous vertigo (episodic vertigo associated with migraine) is sometimes inherited as an autosomal dominant trait. However, neither disease genes nor loci that might be responsible have been reported. We sought to map the genetic locus for familial migrainous vertigo in a 4-generation family and to define the progression of disease in this family.

Methods

We studied 23 members in a family in whom migrainous vertigo was inherited as an autosomal dominant trait. Clinical information obtained included case histories and results of otolaryngological, neurologic, audiometric, and imaging evaluations. Genome-wide linkage analysis was performed with Affymetrix Genechip Human Mapping 10K microarrays. Genotyping of family members' DNA with microsatellite markers was use

SUBMITTER: Bahmad F 

PROVIDER: S-EPMC2767209 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature