The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells.

ABSTRACT: The epithelial-to-mesenchymal transition (EMT) that occurs during embryonic development is recapitulated during tumor metastasis. Important regulators of this process include growth factors, transcription factors, and adhesion molecules. New evidence suggests that microRNA (miRNA) activity contributes to metastatic progression and EMT; however, the mechanisms leading to altered miRNA expression during cancer progression remain poorly understood. Importantly, overexpression of the epidermal growth factor receptor (EGFR) in ovarian cancer correlates with poor disease outcome and induces EMT in ovarian cancer cells. We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3. Overexpression of miR-125a induces conver

SUBMITTER: Cowden Dahl KD 

PROVIDER: S-EPMC2767222 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature