Variation in the human soluble epoxide hydrolase gene and risk of restenosis after percutaneous coronary intervention.

ABSTRACT:

Background

Restenosis represents the major limiting factor for the long-term efficacy of percutaneous coronary intervention (PCI). Several genetic factors involved in the regulation of the vascular system have been described to play a role in the pathogenesis of restenosis. We investigated whether the EPHX2 K55R polymorphism, previously linked to significantly higher risk for coronary heart disease (CHD), was associated with the occurrence of restenosis after PCI. The association with incident CHD should have been confirmed and a potential correlation of the EPHX2 K55R variant to an increased risk of hypertension was analysed.

Methods

An overall cohort of 706 patients was studied: This cohort comprised of 435 CHD patients who had undergone successful PCI. Follow-up coronary

SUBMITTER: Kullmann S 

PROVIDER: S-EPMC2767343 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature