Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae.

ABSTRACT:

Background

The industrially important yeast Saccharomyces cerevisiae is able to grow both in the presence and absence of oxygen. However, the regulation of its metabolism in conditions of intermediate oxygen availability is not well characterised. We assessed the effect of oxygen provision on the transcriptome and proteome of S. cerevisiae in glucose-limited chemostat cultivations in anaerobic and aerobic conditions, and with three intermediate (0.5, 1.0 and 2.8% oxygen) levels of oxygen in the feed gas.

Results

The main differences in the transcriptome were observed in the comparison of fully aerobic, intermediate oxygen and anaerobic conditions, while the transcriptome was generally unchanged in conditions receiving different intermediate levels (0.5, 1.0 or 2.8% O2) of ox

SUBMITTER: Rintala E 

PROVIDER: S-EPMC2767370 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature