Intensive glucose-lowering therapy reduces cardiovascular disease events in veterans affairs diabetes trial participants with lower calcified coronary atherosclerosis.

ABSTRACT:

Objective

This study investigated the hypothesis that baseline calcified coronary atherosclerosis may determine cardiovascular disease events in response to intensive glycemic control within the Veterans Affairs Diabetes Trial (VADT).

Research design and methods

At baseline, 301 type 2 diabetic participants in the VADT, a randomized trial comparing the effects of intensive versus standard glucose lowering on cardiovascular events, had baseline coronary atherosclerosis assessed by coronary artery calcium (CAC) measured by computed tomography. Participants were followed over the 7.5-year study for development of cardiovascular end points.

Results

During a median follow-up duration of 5.2 years, 89 cardiovascular events occurred. Although intensive glucose-lowering thera

SUBMITTER: Reaven PD 

PROVIDER: S-EPMC2768182 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature