FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages.

ABSTRACT:

Objective

Macrophages play an important role in the pathogenesis of insulin resistance via the production of proinflammatory cytokines. Our goal is to decipher the molecular linkage between proinflammatory cytokine production and insulin resistance in macrophages.

Research design and methods

We determined cytokine profiles in cultured macrophages and identified interleukin (IL)-1β gene as a potential target of FoxO1, a key transcription factor that mediates insulin action on gene expression. We studied the mechanism by which FoxO1 mediates insulin-dependent regulation of IL-1β expression in cultured macrophages and correlated FoxO1 activity in peritoneal macrophages with IL-1β production profiles in mice with low-grade inflammation or insulin resistance.

Results

FoxO1

SUBMITTER: Su D 

PROVIDER: S-EPMC2768186 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature