In vivo insulin sensitivity and lipoprotein particle size and concentration in black and white children.

ABSTRACT:

Objective

To examine sex-specific black/white differences in lipoprotein profile and the role of visceral adiposity and to assess the relationship between insulin sensitivity and lipoprotein profiles in each group.

Research design and methods

Fasting lipoprotein particle size and concentration and visceral adipose tissue (VAT) were determined in 226 children (117 black, 101 male) aged 8 to <18 years. The relationship between lipoproteins and insulin sensitivity was evaluated in a subset of 194 children (100 black, 88 male) who underwent a hyperinsulinemic-euglycemic clamp.

Results

Black male children had smaller VLDL and black female children had larger HDL size than their white counterparts. Overall, blacks had larger LDL size with no sex-specific race differences. A

SUBMITTER: Burns SF 

PROVIDER: S-EPMC2768221 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature