Genomewide association studies of stroke.

ABSTRACT:

Background

The genes underlying the risk of stroke in the general population remain undetermined.

Methods

We carried out an analysis of genomewide association data generated from four large cohorts composing the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, including 19,602 white persons (mean [+/-SD] age, 63+/-8 years) in whom 1544 incident strokes (1164 ischemic strokes) developed over an average follow-up of 11 years. We tested the markers most strongly associated with stroke in a replication cohort of 2430 black persons with 215 incident strokes (191 ischemic strokes), another cohort of 574 black persons with 85 incident strokes (68 ischemic strokes), and 652 Dutch persons with ischemic stroke and 3613 unaffected persons.

Results

Two int

SUBMITTER: Ikram MA 

PROVIDER: S-EPMC2768348 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature