DKC1 overexpression associated with prostate cancer progression.

ABSTRACT:

Background

Dyskerin encoded by the DKC1 gene is a predominantly nucleolar protein essential for the formation of pseudouridine in RNA and the telomerase RNA subunit hTR. Inherited mutations inactivating dyskerin cause dyskeratosis congenita, a syndrome with progeroid features characterised by skin defects and haematopoiesis failure, as well as cancer susceptibility. In this study, we report DKC1 overexpression in prostate cancers.

Methods

Expression of DKC1 was measured by quantitative RT-PCR in prostate cancer tissues in relation to hTR and the proliferation marker MKI67. Effects of dyskerin downregulation on proliferation, apoptosis and senescence of prostate cancer cell lines were determined.

Results

DKC1 was significantly overexpressed in prostate cancers, particu

SUBMITTER: Sieron P 

PROVIDER: S-EPMC2768451 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature