Ontology highlight
ABSTRACT:
SUBMITTER: Hanaka H
PROVIDER: S-EPMC2768589 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Hanaka Hiromi H Pawelzik Sven-Christian SC Johnsen John Inge JI Rakonjac Marija M Terawaki Kan K Rasmuson Agnes A Sveinbjörnsson Baldur B Schumacher Martin C MC Hamberg Mats M Samuelsson Bengt B Jakobsson Per-Johan PJ Kogner Per P Rådmark Olof O
Proceedings of the National Academy of Sciences of the United States of America 20091021 44
There is strong evidence for a role of prostaglandin E(2) (PGE(2)) in cancer cell proliferation and tumor development. In PGE(2) biosynthesis, cyclooxygenases (COX-1/COX-2) convert arachidonic acid to PGH(2), which can be isomerized to PGE(2) by microsomal PGE-synthase-1 (MPGES-1). The human prostate cancer cell line DU145 expressed high amounts of MPGES-1 in a constitutive manner. MPGES-1 expression also was detectable in human prostate cancer tissues, where it appeared more abundant compared w ...[more]