Molecular models for intrastrand DNA G-quadruplexes.

ABSTRACT:

Background

Independent surveys of human gene promoter regions have demonstrated an overrepresentation of G(3)X(n1)G3X(n2)G(3)X(n3)G(3) motifs which are known to be capable of forming intrastrand quadruple helix structures. In spite of the widely recognized importance of G-quadruplex structures in gene regulation and growing interest around this unusual DNA structure, there are at present only few such structures available in the Nucleic Acid Database. In the present work we generate by molecular modeling feasible G-quadruplex structures which may be useful for interpretation of experimental data.

Results

We have used all quadruplex DNA structures deposited in the Nucleic Acid Database in order to select a list of fragments entailing a strand of three adjacent G's paired with

SUBMITTER: Fogolari F 

PROVIDER: S-EPMC2768733 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature