Gene networks in Drosophila melanogaster: integrating experimental data to predict gene function.

ABSTRACT:

Background

Discovering the functions of all genes is a central goal of contemporary biomedical research. Despite considerable effort, we are still far from achieving this goal in any metazoan organism. Collectively, the growing body of high-throughput functional genomics data provides evidence of gene function, but remains difficult to interpret.

Results

We constructed the first network of functional relationships for Drosophila melanogaster by integrating most of the available, comprehensive sets of genetic interaction, protein-protein interaction, and microarray expression data. The complete integrated network covers 85% of the currently known genes, which we refined to a high confidence network that includes 20,000 functional relationships among 5,021 genes. An analysis o

SUBMITTER: Costello JC 

PROVIDER: S-EPMC2768986 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature