Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival.

ABSTRACT:

Purpose

Activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, is required for normal growth and is elevated in many cancers, including colorectal cancer. We examined associations of the +316 ODC1 single nucleotide polymorphism (SNP) with colorectal cancer-specific survival among colorectal cancer cases, and then investigated its functional significance in colon cancer cells.

Experimental design

The study included 400 incident stage I-III colorectal cancer cases from the population-based University of California Irvine Gene-Environment Study of Familial Colorectal Cancer (diagnosed from 1994 to 1996 with follow-up through March 2008). The primary outcome was colorectal cancer-specific survival dependent on ODC1 (rs2302615) genotype (GG versus GA/

SUBMITTER: Zell JA 

PROVIDER: S-EPMC2769500 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature