Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands.

ABSTRACT:

Background

High blood pressure or hypertension is a major risk factor involved in the development of cardiovascular diseases. We conducted genome-wide variance component linkage analyses to search for loci influencing five blood pressure related traits including the quantitative traits systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP), the dichotomous trait hypertension (HT) and the bivariate quantitative trait SBP-DBP in families residing in American Samoa and Samoa, as well as in the combined sample from the two polities. We adjusted the traits for a number of environmental covariates such as smoking, alcohol consumption, physical activity and material life style.

Results

We found suggestive univariate linkage for SBP on chromosome 2q35-

SUBMITTER: Aberg K 

PROVIDER: S-EPMC2770055 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature