Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome.

ABSTRACT: Human septic shock involves multiple genome-level perturbations. We have conducted microarray analyses in children with septic shock within 24 h of intensive care unit admission, using whole blood-derived RNA. Based on sequential statistical and expression filters, there were 2,482 differentially regulated gene probes (1,081 upregulated and 1,401 downregulated) between patients with septic shock (n = 42) and controls (n = 15). Both gene lists encompassed several biologically relevant gene ontologies and canonical pathways. Notably, many of the genes downregulated in the patients with septic shock, relative to the controls, participate in gene ontologies related to metal or zinc homeostasis. Comparison of septic shock survivors (n = 33) and nonsurvivors (n = 9) demonstrated differential reg

SUBMITTER: Wong HR 

PROVIDER: S-EPMC2770262 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature