Co-expression among constituents of a motif in the protein-protein interaction network.

ABSTRACT: Almost all cellular functions are the results of well-coordinated interactions between various proteins. A more connected hub or motif in the interaction network is expected to be more important, and any perturbation in this motif would be more damaging to the smooth performance of the related functions. Thus, some coherent robustness of these hubs has to be derived. Here, we provide the global evidence that interaction hubs obtain their robustness against uneven protein concentrations through co-expression of the constituents, and that the degree of co-expression correlates strongly with the complexity of the embedded motif. We calculated the gene expression correlations between the proteins embedded in 3-, 4-, 5-, and 6-node interaction motifs of increasing complexities, and compared the

SUBMITTER: Bhardwaj N 

PROVIDER: S-EPMC2770376 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature