Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.

ABSTRACT: Inflammatory bowel disease (IBD) is a common inflammatory disorder with complex etiology that involves both genetic and environmental triggers, including but not limited to defects in bacterial clearance, defective mucosal barrier and persistent dysregulation of the immune response to commensal intestinal bacteria. IBD is characterized by two distinct phenotypes: Crohn's disease (CD) and ulcerative colitis (UC). Previously reported GWA studies have identified genetic variation accounting for a small portion of the overall genetic susceptibility to CD and an even smaller contribution to UC pathogenesis. We hypothesized that stratification of IBD by age of onset might identify additional genes associated with IBD. To that end, we carried out a GWA analysis in a cohort of 1,011 individuals wi

SUBMITTER: Kugathasan S 

PROVIDER: S-EPMC2770437 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature