Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas.

ABSTRACT:

Background

Chemotherapy resistance remains a major obstacle in the treatment of women with ovarian cancer. Establishing predictive markers of chemoresponse would help to individualize therapy and improve survival of ovarian cancer patients. Chemotherapy resistance in ovarian cancer has been studied thoroughly and several non-overlapping single genes, gene profiles and copy number alterations have been suggested as potential markers. The objective of this study was to explore genetic alterations behind chemotherapy resistance in ovarian cancer with the ultimate aim to find potential predictive markers.

Methods

To create the best opportunities for identifying genetic alterations of importance for resistance, we selected a homogenous tumor material concerning histology, stage a

SUBMITTER: Osterberg L 

PROVIDER: S-EPMC2770569 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature