Ontology highlight
ABSTRACT:
SUBMITTER: Fathallah-Shaykh HM
PROVIDER: S-EPMC2770617 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Fathallah-Shaykh Hassan M HM Bona Jerry L JL Kadener Sebastian S
Biophysical journal 20091101 9
Eukaryotic circadian clocks include interconnected positive and negative feedback loops. The clock-cycle dimer (CLK-CYC) and its homolog, CLK-BMAL1, are key transcriptional activators of central components of the Drosophila and mammalian circadian networks, respectively. In Drosophila, negative loops include period-timeless and vrille; positive loops include par domain protein 1. Clockwork orange (CWO) is a recently discovered negative transcription factor with unusual effects on period, timeles ...[more]