Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study.

ABSTRACT:

Objective

To assess the effect of armodafinil, 150 mg, on the physiologic propensity for sleep and cognitive performance during usual night shift hours in patients with excessive sleepiness associated with chronic (> or =3 months) shift work disorder (SWD) of moderate or greater severity.

Patients and methods

This 12-week, randomized controlled study was conducted at 42 sleep research facilities in North America from April 2 through December 23, 2004, and enrolled 254 permanent or rotating night shift workers with SWD. Entry criteria included excessive sleepiness during usual night shifts for 3 months or longer (corroborated by mean sleep latency of < or =6 minutes on a Multiple Sleep Latency Test), insomnia (sleep efficiency < or =87.5% during daytime sleep), and SWD that w

SUBMITTER: Czeisler CA 

PROVIDER: S-EPMC2770907 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature