The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

ABSTRACT:

Background

Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population.

Methods

The risk associated with genotypes and haplotypes of four TGFB1 SNPs and four VEGF SNPs were determined by multivariate logistic regression analysis in 171 patients with gastric cancer and 353 cancer-free controls frequency-matched by age, sex and ethnicity.

Results

Compared with the VEGF-634GG genotype, the -634CG genotype and the combined -634CG+CC genotypes were asso

SUBMITTER: Guan X 

PROVIDER: S-EPMC2771032 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature