Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation.

ABSTRACT:

Rationale

Glutamate is a major signaling molecule that binds to glutamate receptors including the ionotropic glutamate receptors; kainate (KA) receptor (KAR), the N-methyl-d-aspartate receptor, and the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor. Each is well characterized in the central nervous system, but glutamate has important signaling roles in peripheral tissues as well, including a role in regulating platelet function.

Objective

Our previous work has demonstrated that glutamate is released by platelets in high concentrations within a developing thrombus and increases platelet activation and thrombosis. We now show that platelets express a functional KAR that drives increased agonist induced platelet activation.

Methods and results

KAR indu

SUBMITTER: Sun H 

PROVIDER: S-EPMC2771168 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature