Chemokine receptors and other G protein-coupled receptors.

ABSTRACT:

Purpose of review

Class A G protein-coupled receptors (GPCRs), including the chemokine receptors, CCR5 and CXCR4, share a seven transmembrane-spanning alpha-helix architecture that accommodates signal propagation from across biological membranes. CXCR4 and CCR5 are utilized as co-receptors during HIV viral entry and, therefore, crystal structures of GPCRs aid in the understanding of their function in viral entry.

Recent findings

Recent progress in structure determination of class A GPCRs, which include vertebrate and invertebrate rhodopsin as well as adrenergic and adenosine receptors, provides molecular templates for how this diverse group of transmembrane receptors functions. Each of these GPCRs differs in how specific ligands bind to the transmembrane core, underscoring t

SUBMITTER: Lodowski DT 

PROVIDER: S-EPMC2771364 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature