Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is an umbrella designation that includes a heterogeneous group of primary brain tumors. Several classification strategies of GBM have been reported, some by clinical course and others by resemblance to cell types either in the adult or during development. From a practical and therapeutic standpoint, classifying GBMs by signal transduction pathway activation and by mutation in pathway member genes may be particularly valuable for the development of targeted therapies.

Methodology/principal findings

We performed targeted proteomic analysis of 27 surgical glioma samples to identify patterns of coordinate activation among glioma-relevant signal transduction pathways, then compared these results with integrated analysis of genomic and expr

SUBMITTER: Brennan C 

PROVIDER: S-EPMC2771920 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature