A 5' leader sequence regulates expression of methanosarcinal CO dehydrogenase/acetyl coenzyme A synthase.

ABSTRACT: In vivo expression of CO dehydrogenase/acetyl coenzyme A synthase in Methanosarcina spp. is coordinately regulated in response to substrate by at least two mechanisms: differential transcription initiation and early elongation termination near the 3' end of a 371-bp leader sequence. This is the first report of regulation of transcription elongation in the Archaea.

SUBMITTER: Anderson KL 

PROVIDER: S-EPMC2772459 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature