An interactive regulatory network controls stress response in Bifidobacterium breve UCC2003.

ABSTRACT: Members of the genus Bifidobacterium are gram-positive bacteria that commonly are found in the gastrointestinal tract (GIT) of mammals, including humans. Because of their perceived probiotic properties, they frequently are incorporated as functional ingredients in food products. From probiotic production to storage and GIT delivery, bifidobacteria encounter a plethora of stresses. To cope with these environmental challenges, they need to protect themselves through stress-induced adaptive responses. We have determined the response of B. breve UCC2003 to various stresses (heat, osmotic, and solvent) using transcriptome analysis, DNA-protein interactions, and GusA reporter fusions, and we combined these with results from an in silico analysis. The integration of these results allowed the form

SUBMITTER: Zomer A 

PROVIDER: S-EPMC2772463 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature