Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance.

ABSTRACT: Drug resistance is an important cause of antiretroviral therapy failure in human immunodeficiency virus (HIV)-infected patients. Mutations in the protease render the virus resistant to protease inhibitors (PIs). Gag cleavage sites also mutate, sometimes correlating with resistance mutations in the protease, but their contribution to resistance has not been systematically analyzed. The present study examines mutations in Gag cleavage sites that associate with protease mutations and the impact of these associations on drug susceptibilities. Significant associations were observed between mutations in the nucleocapsid-p1 (NC-p1) and p1-p6 cleavage sites and various PI resistance-associated mutations in the protease. Several patterns were frequently observed, including mutations in the NC-p1 cl

SUBMITTER: Kolli M 

PROVIDER: S-EPMC2772784 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature