Characterization of the oxidative stress stimulon and PerR regulon of Campylobacter jejuni.

ABSTRACT:

Background

During gut colonization, the enteric pathogen Campylobacter jejuni must surmount the toxic effects of reactive oxygen species produced by its own metabolism, the host immune system, and intestinal microflora. Elucidation of C. jejuni oxidative stress defense mechanisms is critical for understanding Campylobacter pathophysiology.

Results

The mechanisms of oxidative stress defense in C. jejuni were characterized by transcriptional profiling and phenotypic analysis of wild-type and mutant strains. To define the regulon of the peroxide-sensing regulator, PerR, we constructed an isogenic DeltaperR mutant and compared its transcriptome profile with that of the wild-type strain. Transcriptome profiling identified 104 genes that belonged to the PerR regulon. PerR appears

SUBMITTER: Palyada K 

PROVIDER: S-EPMC2772861 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature