Analysis of regulatory protease sequences identified through bioinformatic data mining of the Schistosoma mansoni genome.

ABSTRACT:

Background

New chemotherapeutic agents against Schistosoma mansoni, an etiological agent of human schistosomiasis, are a priority due to the emerging drug resistance and the inability of current drug treatments to prevent reinfection. Proteases have been under scrutiny as targets of immunological or chemotherapeutic anti-Schistosoma agents because of their vital role in many stages of the parasitic life cycle. Function has been established for only a handful of identified S. mansoni proteases, and the vast majority of these are the digestive proteases; very few of the conserved classes of regulatory proteases have been identified from Schistosoma species, despite their vital role in numerous cellular processes. To that end, we identified protease protein coding genes from the S. ma

SUBMITTER: Bos DH 

PROVIDER: S-EPMC2772863 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature