Emerging treatments for traumatic brain injury.

ABSTRACT:

Background

This review summarizes promising approaches for the treatment of traumatic brain injury (TBI) that are in either preclinical or clinical trials.

Objective

The pathophysiology underlying neurological deficits after TBI is described. An overview of select therapies for TBI with neuroprotective and neurorestorative effects is presented.

Methods

A literature review of preclinical TBI studies and clinical TBI trials related to neuroprotective and neurorestorative therapeutic approaches is provided.

Results/conclusion

Nearly all Phase II/III clinical trials in neuroprotection have failed to show any consistent improvement in outcome for TBI patients. The next decade will witness an increasing number of clinical trials that seek to translate preclinical res

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC2773142 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature