Importance of charge independent effects in readout of the trimethyllysine mark by HP1 chromodomain.

ABSTRACT: Histone modifications are implicated in epigenetic inheritance and are of central importance in regulating chromatin structure and gene expression. A prototype example is the trimethylation (Me3) of lysine 9 on histone 3 (H3), which is a readout by an aromatic cage of the chromodomain of heterochromatin-associated protein 1 (HP1) thereby leading to transcriptional repression and heterochromatin formation. Considering that the lysine methylation does not change the charge state of the histone tail and such aromatic-cage mediated recognition of the quaternary ammonium moiety is emerging as the most striking mechanistic commonality for the state-specific recognition of histone lysine methylation, it is of particular interest and importance to understand the physical origin regarding how the a

SUBMITTER: Lu Z 

PROVIDER: S-EPMC2773244 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature