TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.

ABSTRACT:

Background

TCF7L2 polymorphisms have been consistently associated with type 2 diabetes mellitus in different populations and type 2 diabetes mellitus is a major risk factor for cardiovascular disease, especially coronary artery disease. This study aimed to evaluate the association between TCF7L2 polymorphism rs7903146 and coronary artery disease in diabetic and non-diabetic subjects.

Methods and results

two populations were studied in order to assess severity of coronary artery disease and cardiovascular events incidence. Eight-hundred and eighty nine subjects who were referred for cardiac catheterization for coronary artery disease diagnosis were cross-sectionally evaluated for coronary lesions (atherosclerotic burden) and 559 subjects from the MASS-II Trial were prospectiv

SUBMITTER: Sousa AG 

PROVIDER: S-EPMC2773425 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature