Effects of asymptomatic proximal and distal gastroesophageal reflux on asthma severity.

ABSTRACT:

Rationale

Silent gastroesophageal reflux (GER) is common in patients with asthma, but it is unclear whether GER is associated with worse asthma symptoms or reduced lung function.

Objectives

To determine in patients with poorly controlled asthma, whether proximal or distal esophageal reflux is associated with asthma severity, symptoms, physiology, or functional status.

Methods

Baseline asthma characteristics were measured in patients with asthma enrolled in a multicenter trial assessing the effectiveness of esomeprazole on asthma control. All participants underwent 24-hour esophageal pH probe monitoring. Lung function, methacholine responsiveness, asthma symptoms, and quality-of-life scores were compared in subjects with and without GER.

Measurements and main result

SUBMITTER: DiMango E 

PROVIDER: S-EPMC2773912 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature