MicroRNome analysis unravels the molecular basis of SARS infection in bronchoalveolar stem cells.

ABSTRACT: Severe acute respiratory syndrome (SARS), caused by the coronavirus SARS-CoV, is an acute infectious disease with significant mortality. A typical clinical feature associated with SARS is pulmonary fibrosis and associated lung failure. In the aftermath of the SARS epidemic, although significant progress towards understanding the underlying molecular mechanism of the infection has been made, a large gap still remains in our knowledge regarding how SARS-CoV interacts with the host cell at the onset of infection. The rapidly changing viral genome adds another variable to this equation. We have focused on a novel concept of microRNA (miRNA)-mediated host-virus interactions in bronchoalveolar stem cells (BASCs) at the onset of infection by correlating the "BASC-microRNome" with their targets wi

SUBMITTER: Mallick B 

PROVIDER: S-EPMC2773932 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature