Ontology highlight
ABSTRACT:
SUBMITTER: Area-Gomez E
PROVIDER: S-EPMC2774047 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
The American journal of pathology 20091015 5
Presenilin-1 (PS1) and -2 (PS2), which when mutated cause familial Alzheimer disease, have been localized to numerous compartments of the cell, including the endoplasmic reticulum, Golgi, nuclear envelope, endosomes, lysosomes, the plasma membrane, and mitochondria. Using three complementary approaches, subcellular fractionation, gamma-secretase activity assays, and immunocytochemistry, we show that presenilins are highly enriched in a subcompartment of the endoplasmic reticulum that is associat ...[more]