Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.

ABSTRACT:

Context

Many individuals take vitamins in the hopes of preventing chronic diseases such as cancer, and vitamins E and C are among the most common individual supplements. A large-scale randomized trial suggested that vitamin E may reduce risk of prostate cancer; however, few trials have been powered to address this relationship. No previous trial in men at usual risk has examined vitamin C alone in the prevention of cancer.

Objective

To evaluate whether long-term vitamin E or C supplementation decreases risk of prostate and total cancer events among men.

Design, setting, and participants

The Physicians' Health Study II is a randomized, double-blind, placebo-controlled factorial trial of vitamins E and C that began in 1997 and continued until its scheduled completion on

SUBMITTER: Gaziano JM 

PROVIDER: S-EPMC2774210 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature