Sex hormone-binding globulin and risk of type 2 diabetes in women and men.

ABSTRACT:

Background

Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain.

Methods

We performed a nested case-control study of postmenopausal women in the Women's Health Study who were not using hormone therapy (359 with newly diagnosed type 2 diabetes and 359 controls). Plasma levels of sex hormone-binding globulin were measured; two polymorphisms of the gene encoding sex hormone-binding globulin, SHBG, that were robustly associated with the protein levels were genotyped and applied in mendelian randomization analyses. We then conducted a replication study in an independent cohort of men from the Physicians' Health Study II (170 with newly diagnosed ty

SUBMITTER: Ding EL 

PROVIDER: S-EPMC2774225 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature