Correlating global gene regulation to angiogenesis in the developing chick extra-embryonic vascular system.

ABSTRACT:

Background

Formation of blood vessels requires the concerted regulation of an unknown number of genes in a spatial-, time- and dosage-dependent manner. Determining genes, which drive vascular maturation is crucial for the identification of new therapeutic targets against pathological angiogenesis.

Methodology/principal findings

[corrected] We accessed global gene regulation throughout maturation of the chick chorio-allantoic membrane (CAM), a highly vascularized tissue, using pan genomic microarrays. Seven percent of analyzed genes showed a significant change in expression (>2-fold, FDR<5%) with a peak occurring from E7 to E10, when key morphogenetic and angiogenic genes such as BMP4, SMO, HOXA3, EPAS1 and FGFR2 were upregulated, reflecting the state of an activated endothel

SUBMITTER: Javerzat S 

PROVIDER: S-EPMC2774277 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature