Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression.

ABSTRACT:

Background

Selenium, a micronutrient whose deficiency in diet causes immune dysfunction and inflammatory disorders, is thought to exert its physiological effects mostly in the form of selenium-containing proteins (selenoproteins). Incorporation of selenium into the amino acid selenocysteine (Sec), and subsequently into selenoproteins is mediated by Sec tRNA([Ser]Sec).

Results

To define macrophage-specific selenoprotein functions, we generated mice with the Sec tRNA([Ser]Sec) gene specifically deleted in myeloid cells. These mutant mice were devoid of the "selenoproteome" in macrophages, yet exhibited largely normal inflammatory responses. However, selenoprotein deficiency led to aberrant expression of extracellular matrix-related genes, and diminished migration of macrophage

SUBMITTER: Carlson BA 

PROVIDER: S-EPMC2774298 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature